Upstate Medical University

Exclusion Criteria

  • Do you have evidence of new or prior non-traumatic intracerebral hemorrhage, subarachnoid hemorrhage, or subdural hemorrhage on initial head computed tomography?
  • Do you have evidence of a CNS tumor, abscess, intracranial aneurysm, vascular/structural malformation, or any neuroinflammatory, neuroinfectious, neurodegenerative disorders or any neuroimaging scan or exam that could confound your functional outcome?
  • Do you have any isolated or pure sensory, visual changes, dizziness or vertigo without evidence of AIS on baseline head CT or MRI?
  • Do you have a qualifying ischemic event that is believed to be iatrogenic or procedure related
  • Are you required to take a specific antiplatelet medication for an indication other than ischemic stroke or high-risk TIA during the study period that would prevent the investigator from following the study algorithm? 
  • Do you have etiology of a qualifying ischemic event that is known to be cardioembolic?
  • Is there a high likelihood that you will need an anticoagulant (warfarin, NOACs, Lovenox) during the study period?
  • Is there a high likelihood that carotid endarterectomy or carotid stenting will occur during the period of the study?
  • Do you have a pre-stroke mRS score of 3 or more?
  • Do you have a simple FRAIL questionnaire screening tool score of 3 or more?
  • Do you have any contraindications to aspirin, clopidogrel, Aggrenox, or ticagrelor?
  • Do you have any known allergies or hypersensitivities that would prevent the investigator from following the study algorithm?
  • Do you have any history of moderate to severe drug-induced adverse events?
  • Do you have any renal insufficiencies or hepatic impairments?
  • Do you have Class II, III, or IV of New York Heat Association (NYHA) functional heart failure?
  • Do you have any history of bradycardia without placement of a pacemaker?
  • Do you have active obstructive lung disease?
  • Do you have any active hematologic disorders?
  • Do you have active bleeding diathesis?
  • Have you had any systemic hemorrhage or GI bleeding in the 3 months prior to the qualifying stroke?
  • Do you have active peptic ulcer disease?
  • Are you pregnant or breastfeeding?
  • Do you have an active alcohol or substance abuse or dependence?
  • Are you unable to provide informed consent?
  • Are you unable to adhere to study procedures and follow up?
  • Are you unable to swallow oral medication?
  • Are you unwilling or unable to discontinue prohibited concomitant medications?
  • Are you currently participating in another non-observational clinical study?